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Ãâ»ýÈÄ ¼ºÀå¹ßÀ°¿¡ µû¸¥ ÈòÁã À¯°ûÀ¯µÎÀÇ CGRP ¸é¿ª¾ç¼º ½Å°æºÐÆ÷º¯È­

POSTNATAL DEVELOPMENT OF CGRP-IMMUNOREACTIVE NERVE DISTRIBUTION OF RAT CIRCUMVALLATE PAPILLA

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Abstract

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Ãâ»ý ÈÄ ¼ºÀå ¹ßÀ°¿¡ µû¸¥ ÈòÁã À¯°ûÀ¯µÎÀÇ ½Å°æºÐÆ÷ ¹× º¯È­¸¦ °üÂûÇϱâ À§ÇÏ¿© »ýÈÄ 1,
5, 10, 15, 20, 25, 35ÀÏ ¹× ¿ÏÀüÈ÷ ¼ºÀåÇÑ ÈºÁ㸦 ´ë»óÀ¸·Î calcitonin gene-related
peptide(CGRP)¸¦ ÀÌ¿ëÇÑ ¸é¿ªÁ¶Á÷È­ÇÐÀû ¹æ¹ýÀ¸·Î °üÂûÇÏ¿© ´ÙÀ½°ú °°Àº °á°ú¸¦ ¾ò¾ú´Ù.
CGRP-¸é¿ª¾ç¼º ½Å°æ¼¶À¯µéÀÌ ÇôÀÇ ¾çÃø¿¡¼­ºÎÅÍ À¯µÎ ³»·Î ÁøÀÔÇÏ¿© ¼ºÀå¹ßÀ°¿¡ µû¶ó ±×
ºÐÆ÷¹Ðµµ°¡ Áõ°¡ÇÏ´Ù°¡ 10ÀϱººÎÅÍ´Â »óÇÇÀÇ Á÷ÇϹ濡 ƯÈ÷ dzºÎÇÏ°Ô ºÐÆ÷ÇÏ¿©
subepithelial plexus¸¦ Çü¼ºÇÏ°í ÀÖ¾ú´Ù.
1Àϱº¿¡¼­´Â CGRP-¸é¿ª¾ç¼º ½Å°æ¼¶À¯ÀÇ Æ¯Â¡ÀûÀÎ ¾ç»óÀÎ ¿°ÁÖ¾Ë ¸ð¾çÀÌ ¸íÈ®È÷ °üÂûµÇ¾ú
À¸³ª ±× ÀÌÈķδ ¿°ÁÖ¾Ë ¸ð¾çÀº ´Ù¼Ò °¨¼ÒÇÏ¿´°í ÇϳªÀÇ ¼±À¸·Î º¸ÀÌ´Â °æ¿ìµµ ÀÖ¾ú´Ù.
»óÇÇ ³»·Î ÁøÀÔÇÏ´Â CGRP-¸é¿ª¾ç¼º ½Å°æ¼¶À¯µéÀº 5Àϱº¿¡¼­ µå¹°°Ô °üÂûµÇ¾úÀ¸¸ç taste
pore¸¦ °¡Áø ¼º¼÷ÇÑ ¹Ì·Ú°¡ óÀ½À¸·Î °üÂûµÇ´Â 10Àϱº¿¡¼­ ±× ¼ö°¡ Áõ°¡ÇÏ¿© Ãâ»ý ÈÄ 15ÀÏ
±º¿¡¼­´Â »óÇÇ Àü¹Ý¿¡ °ÉÃÄ Ç³ºÎÇÏ°Ô °üÂûµÇ¾ú´Ù. ±×·¯³ª ±× ÀÌÈÄ 20ÀϱººÎÅÍ´Â ¹Ì·Ú°¡ Á¸
ÀçÇÏ´Â trench wallÀÇ ÇϹæ 2/3ºÎÀ§ÀÇ CGRP-¸é¿ª¾ç¼º ½Å°æ¼¶À¯´Â °¨¼ÒÇÏ°í À¯µÎÀÇ top
surface¿Í trench wallÀÇ »ó¹æ 1/3¿¡ CGRP-¸é¿ª¾ç¼º ½Å°æ¼¶À¯°¡ Á¦ÇÑÀûÀ¸·Î °üÂûµÇ¾ú´Ù.
#ÃÊ·Ï#
The purpose of this study was to investigate the distribution of nerves in the rat
circumvallate papilla by each developing stage.
The distribution of nerves in the rat circumvallate papilla were investigated by means
of immunohistochemistry for detection of calcitonin gene-related peptide(CGRP).
The results were as follows : CGRP-immunoreactive(IR) nerve fibers entered the base
of the papilla laterally to form a subepithelial plexus.
On the 1st postnatal day, the bead-like appearance, typical appearance of CGRP-IR
nerve fiber, was seen, but from the 5th postnatal day the bead-like appearance was
seen less clearly and nerve fibers looking like a line were often observed.
Mature taste buds having taste pores were first seen at the 10th postnatal day and
then, increased markedly after this stage.
CGRP-IR nerve fibers entering the epithelium were rarely seen on the 5th postnatal
day but they increased in number on the 10th postnatal day when mature taste buds
having taste pores were firstly observed and then on the 15th postnatal day, they were
observed abundantly throughout entire epithelium. But from the 20th postnatal day, the
nerve fibers in the lower two-third of the trench wall in which taste buds exist
decreased but on the top surface and upper one-third of the trench wall the nerve fibers
were observed limitedly.

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